Coronavirus vaccine: the three drugs racing to rid the world of Covid-19
Published : Tuesday, 24 November, 2020 at 6:46 PM Count : 138
The race is on to be the first to make a safe and effective coronavirus vaccine.
So far, three main partnerships have emerged as the front-runners to provide the world with the vaccine that could return life to normal for billions of people.
So what are the ones you need to know about and how do they work?
This month, the US-German venture published findings that their vaccine stops 90 per cent of people from developing symptoms of coronavirus. Injected in the muscle, the vaccine is given in two doses, three weeks apart.
It has been tested on 43,538 in six countries including Turkey, the US and Germany.
The UK has already ordered 40 million doses. Pfizer had applied to get approval from the US Food and Drug Administration for emergency use of the vaccine. The FDA will meet on December 10th to discuss the authorisation.
Studies show that Pfizer's vaccine is equally effective across ages and ethnicities.
At anywhere between $25-37 a dose, like Pfizer, this vaccine uses a technology known as synthetic messenger RNA (mRNA) which has never been officially used before for infectious diseases.
In contrast to regular vaccines, which train the body's immune system to respond to a bacteria or virus, mRNA vaccines actually dupe the body into producing its own virus.
"Using mRNA as a drug opens up a breadth of opportunities to treat and prevent disease. mRNA medicines can go inside cells to direct protein production, something not possible with other drug approaches," Moderna said.
Experimentally, the Moderna vaccine is 94.5 per cent effective in preventing Covid-19.
Late stage trials are still underway though the vaccine is being studied in 30,000 volunteers who received either the real thing or a dummy shot. Recently, an independent monitoring board examined 95 infections that were recorded after volunteers' second shot, only five were in people given the vaccine. The company aims to file for emergency use with the FDA as well.
Oxford University announced on Monday the Oxford/AstraZeneca vaccine is currently 70.4 per cent effective at preventing the coronavirus. Tested in two different dosages, the vaccine proved In the 90 per cent and 62 per cent effective respectively with more efficacy found in the higher dose. Some 24,000 volunteers in the UK, Brazil and South Africa participated in the trials. British Prime Minister Boris Johnson called the news from Oxford "incredibly exciting" despite further safety checks being required.
Named after the Soviet Union's Sputnik satellite, this two-dose vaccine is set to cost less than $10 a dose. Developed by Russia's Ministry of Health and its investment fund, trial results show it at 91.4 efficacy on 18,794 volunteers.
Free of charge for Russians, the vaccine uses a decades long medical science involving human adenoviral vectors.
The Russian government said it had received requests from over 50 countries for the vaccination totalling to 1.2 billion doses of the vaccine.