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What causes the excess deaths in males?

Published : Tuesday, 11 August, 2020 at 12:00 AM  Count : 705
M Zakir Hossin

What causes the excess deaths in males?

What causes the excess deaths in males?

Women are typically considered to be the weaker sex. Men are on average taller, more muscular, and seemingly stronger than women. Medical science, however, has a different story to tell us: women are biologically stronger than men. In all countries across the world, women consistently live longer than men on average. This is also true for many other species of mammals.
 
The ongoing coronavirus pandemic further reminds us of the gender gap in mortality. In countries with available data, Covid-19 has been found to be killing more men than women.  In Bangladesh, Covid-19 mortality is so far four times higher in men compared to women. The higher prevalence of fatal diseases in men and the stronger immune system in women are presumably driving the gender differences in Covid-19 mortality globally.

The natural sex ratio at birth is male-biased, with 105 boys born globally against 100 girls. As the offspring grow up, males die in greater numbers than females, leading to a more balanced sex ratio in adult ages. The population sex ratio again reverses in old ages, with women outnumbering men in most countries. Consequently, around 90% of all supercentenarians living on the planet today are women.

Women usually report more psychological problems while men suffer more from severe and life-threating illnesses like heart diseases, stroke and cancer. These diseases are the major killers of our time and the main culprits for premature deaths and gender gap in mortality worldwide.

Women face discriminations at every sphere of the society, which limit their potential to maximize health and wellbeing. Yet, they paradoxically seem to be the healthier sex. Several biological and social mechanisms may be suggested to explain the gender-health paradox.

From a biologic point of view, men are naturally programmed to die earlier than women at the very moment of conception. The male fetus is biologically weaker and more vulnerable to pregnancy complications than the female fetus. Moreover, the neonatal and infant mortality rates are higher in boys compared to girls. These sex differences at birth provide the foundation for the biologic explanation of male disadvantage in life-expectancy.

The sex hormones are argued to play a crucial role in the female advantage in longevity. The female sex hormone estrogen is protective of cardiovascular diseases and is partly responsible for lower incidence of such diseases in women until menopause. By contrast, the androgen hormone, which is higher in men, is associated with higher risk of cardiovascular diseases.
 
The stronger immune system of the females is another factor that could contribute to the longevity gap. Female bodies are known to produce larger amounts of antibodies compared to males. This offers females an increased capacity to fight off respiratory, bacterial, and viral infections including the deadly Covid-19.

Moreover, female bodies carry higher amounts of the beneficial cholesterol (HDL) which protects against heart diseases. Men are disadvantaged even in the distribution of fat because they tend to accumulate excess fat around the stomach while women tend to carry excess fat in the hips and thighs. Any excess fat is harmful, but the abdominal fat is more dangerous for cardiovascular health.

Genetic disorders are sometimes held responsible for excess morality in men. A damaged gene on the X chromosome can be naturally compensated by a similar gene in the second X chromosome in women, but not in men due to the lack of double X chromosomes.

Furthermore, the mitochondrial DNA, which is known as the powerhouse of cells and is believed to be exclusively inherited from the mother, leads to male-specific harmful mutations in the mitochondria. The mitochondrial dysfunction is associated with ageing and chronic diseases.

If biology were the sole cause behind the gender gap in life-expectancy, one could expect the gap to be relatively constant over time and across societies. However, the gap varies by time and contexts, suggesting that social forces are in operation to drive the trends. A Bangladeshi boy born today is expected to live 3.8 years shorter than a girl while the corresponding male-female gap is 10.5 years in Russia.

Thanks to medical advances and improved standard of living, global life-expectancy linearly went up by three months per year (i.e., 6 hours a day) from 1841 to 2000.

Men are more exposed to work-related stress and unhealthy behaviours, e.g., smoking and alcohol abuse, which are held responsible for their lower longevity. As a result, they die disproportionately in work-related accidents, car crashes, war, and sporting activities.

The male sex hormone testosterone is believed to be responsible for predisposing men to risky behaviours. This is why, perhaps, research finds a link between marriage and increased life-expectancy in men but not in women.  

Compared to the past, the gender gap in global life-expectancy has narrowed in recent years. This is unsurprising given that women are increasingly entering the workforce and adopting health-damaging lifestyles like smoking and drinking. An interesting case in point is Sweden where females smoke more than males and the male-female longevity gap is relatively low. Improved medical management of fatal diseases might also have contributed to the reduced gap.

Women are evidently the healthier sex and real champions in the ultimate game of life. Nature has given women a biological advantage over men, perhaps to compensate the structural disadvantages they experience in the society. Biology is, of course, only a part of the full story since it cannot answer why the female advantage in life expectancy would fluctuate over time.

The biological gap in life-expectancy between women and men is a natural destiny which no society can avoid. However, the social gap in life-expectancy is unjust and unfair. We can rarely alter our biological make-up, but we can certainly promote healthy lifestyles and design a society where both men and women will have a fair chance to maximize their health potentials.
 
The writer is a Managing Editor at the European Journal of Public Health, Oxford University Press, UK and a PhD fellow at Karolinska Institute, Stockholm, Sweden








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